Methyl 4-(4'-fluoro-4-biphenylyl)-4-oxo-butyrate → 4-(4'-Fluoro-4-biphenylyl)-4-oxo-butyric acid

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Reaction Steps

A suspension of 4-(4′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (6.08 g, 0.0212 mol) in 6 M hydrochloric acid was refluxed for 22 hours and cooled to room temperature. The solids were filtered and washed with 0.1 M hydrochloric acid. The filter cake was dried under house vacuum (air bleed) to give 5.72 g of 4-(4′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a peach colored solid; mp 173.5-175.5° C.

Provenance & Evidence