HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 4-(4'-Chloro-2'-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid | HCID 18364124 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4'-Chloro-2'-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid | HCID 73432322 | 85.6% |
Reaction Steps
In a manner similar to Example 4, Step (c), 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (1.100 g, 0.00359 mol) was allowed to react with hydroxylamine hydrochloride (0.300 g, 0.00432 mol) in the presence of sodium carbonate (0.458 g, 0.00432 mol) in absolute ethanol (20 mL) to give 0.989 g of 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as an off-white solid; mp 147.5-149.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307089B2 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-8d3d5762f3724840a661e0278a44f5d6 |
| Source note | uspto-grants-2001_10 |