HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorophenylboronic acid → HCID 21933850, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | 4-Chloro-5-methoxy-2-phenyl-3(2H)-pyridazinone | HCID 349842 | — |
| Product | HCID 21933850 | HCID 21933850 | 96% |
Reaction Steps
The 2-phenyl-4-chloro-5-methoxy-3(2H)-pyridazinone product was coupled with 4-fluorophenylboronic acid according to the method of Example 6 to provide 2-phenyl-4-(4-fluorophenyl)-5-methoxy-3(2H)-pyridazinone (yield: 1.1 g; 96%). 1H NMR (300 MHz, CDCl3) δ 4.00 (s, 3H), 7.10 (t, J=9 Hz, 2H), 7.45 (m, 3H), 7.60 (m, 4H), 8.06 (s, 1H). MS (DCI/NH3) m/z 297 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307047B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-efa2b98dca1f45ed9130fed57c87fcfa |
| Source note | uspto-grants-2001_10 |