HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Fluorophenyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Fluoroiodobenzene | HCID 9605 | — |
| Reactant | 4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone | HCID 21934162 | — |
| Product | 4-Fluorophenyl-4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone | HCID 10343937 | — |
Reaction Steps
The title compound was prepared according to Example 93, starting with 4-(4-fluorophenoxy)-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and substituting 1-fluoro-4-iodobenzene in place of 4-bromothioanisole (yield: 60 mg, 53%). mp 83-85° C. 1H NMR (300 MHz, CDCl3) δ 3.10 (s, 3H), 6.89-7.03 (m, 4H), 7.15 (t, J=9 Hz, 2H), 7.65 (dd, J=9 Hz, 6 Hz, 2H), 7.83 (d, J=6 Hz, 2H), 8.07 (d, J=9 Hz, 2H), 8.08 (s, 1H). MS (DCI/NH3) m/z 455 (M+H)+, 472 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307047B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-b6d9f581c8d44462bae2101abe411f5c |
| Source note | uspto-grants-2001_10 |