Ammonia → HCID 21934037, compound

HRID 381929Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14](=[O:15])[C:13]([O:16]S(C3C=CC(C)=CC=3)(=O)=O)=[C:12]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[C:29]([F:37])[CH:28]=3)[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[F:38][C:39]1[CH:44]=[CH:43][C:42](O)=[CH:41][CH:40]=1.N>>[F:1][C:2]1[CH:3]=[C:4]([N:9]2[C:14](=[O:15])[C:13]([O:16][C:42]3[CH:43]=[CH:44][C:39]([F:38])=[CH:40][CH:41]=3)=[C:12]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:34])=[O:35])=[C:29]([F:37])[CH:28]=3)[CH:11]=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 3

HCID 222Ammonia

HCID 97324-Fluorophenol

HCID 21934262HCID 21934262, compound

Product 1

HCID 21934037HCID 21934037, compound

Procedure

The title compound was prepared according to the method of Example 346, starting with 2-(3,4-difluorophenyl)-4-tosyloxy-5-[3-fluoro-4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone in place of 2-(3,4-difluorophenyl)-4-tosyloxy-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone and substituting 4-fluorophenol in place of isobutanol mp 168-170° C. 1H NMR (300 MHz, DMSO-d6) δ 3.39 (s, 3H), 7.15 (d, 4H), 7.51 (m, 1H), 7.6 (m, 1H) 7.75 (m, 3H), 7.97 (t, 1H); 8.4 (s, 1H). MS (DCI/NH3) m/z 491 (M+H)+, 508 (M+NH4)+. Anal. calc. for C23H14F4N2O4S: C, 56.33; H, 2.88; N, 5.71. Found, C, 56.07; H, 2.94; N, 5.33.

Sources & evidence

ORD record: ord-f1443343357b464ea400e47540dee507
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06307047B1

Reaction notes

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