HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopentyldiol → 5-Bromo-2-(3,4-difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)pyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopentyldiol | HCID 247470 | — |
| Reactant | 4,5-Dibromo-2-(3,4-difluorophenyl)pyridazin-3(2H)-one | HCID 15941889 | — |
| Product | 5-Bromo-2-(3,4-difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)pyridazin-3(2H)-one | HCID 21934227 | — |
Reaction Steps
The dibromo-intermediate from Example 471B was reacted according to the procedure described in Example 194B, substituting 3-methyl-1,3-butanediol in place of methanol, to selectively react at the 4-position and provide the title intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307047B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-320d96b657e94f659d4b15839d6a1bd3 |
| Source note | uspto-grants-2001_10 |