反应详情

8.50 g (4.5 mmol) (RS)—S-(4-nitrophenyl)-S-methylsulfoximide in 400 ml pyridine are treated dropwise at room temperature with 18.8 ml (197.2 mmol) ethyl chloroformate. The mixture is stirred at room temperature for 4 hours and then poured into dilute NaCl solution. It is extracted with ethyl acetate. The combined organic phases are dried (Na2SO4), filtered and concentrated. The remaining residue is chromatographically purified (hexane/ethyl acetate 1:1). 8.94 g (32.8 mmol, corresponding to 77% of theor.) of the product is obtained.

1. extractionIt is extracted with ethyl acetate
2. dry with materialThe combined organic phases are dried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated
5. customThe remaining residue is chromatographically purified (hexane/ethyl acetate 1:1)
6. custom8.94 g (32.8 mmol, corresponding to 77% of theor.) of the product is obtained