HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → (RS)-S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | S-Methyl-S-(4-nitrophenyl)sulfoximine | HCID 12463933 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (RS)-S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide | HCID 59550870 | — |
Reaction Conditions
| Temperature | 104 °C |
|---|
Reaction Steps
300 mg (1.5 mmol) (RS)—S-(4-nitrophenyl)-S-methylsulfoximide in 8 ml toluene and 4 ml petroleum ether 60/80 are treated with 0.097 ml (1.65 mmol) methyl isocyanate. The mixture is stirred in a pressure tube at 104° C. for 5 hours and at room temperature for 14 hours. The suspension is filtrated to give 302 mg (corresponding to 78% of theor.) of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524724B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-b9db38281e184972a01fdec5cd6394b7 |
| Source note | uspto-grants-2013_09 |