Boronic acid, [3-[(2-amino-2-oxoethyl)amino]phenyl]- → HCID 54413821, compound

Participants

Reaction Steps

A solution of (Z)-1,3-dihydro-5-fluoro-4-iodo-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one (50 mg, 0.13 mmol), 2M aqueous Na2CO3 solution (0.13 mL) (Starting Material 13), (Ph3P)2PdCl2 (22 mg, 0.027 mmol) and 3-(carbamoylmethyl-amino)-phenylboronic acid (55 mg, 0.26 mmol) in 1,2-dimethoxyethane (5 mL) was heated at 103° C. for 3 days. The reaction mixture was filtered and concentrated. The crude material was purified by C18 reverse phase chromatography to give 2-[3-[5-Fluoro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2-oxo-2,3-dihydro-1H-indol-4-yl]-phenylamino]-acetamide. (Yield 1 5mg, 28%).

Provenance & Evidence