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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 382161Generated: October 30, 2026

4-Bromopyridine → 4-(4-Bromophenyl)pyridine

https://huagongshe.com/reaction/382161

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromopyridineHCID 14268—
Reactant(4-Bromophenyl)boronic acidHCID 79599—
Reactant3-(Biphenyl-4-yl)furanHCID 18380293—
Product4-(4-Bromophenyl)pyridineHCID 616283100%

Reaction Steps

According to the procedure described in Example 1(a) for the preparation of 3-biphenyl-4-yl-furan, 4-bromopyridine (700 mg, 3.00 mmol) underwent coupling to 4-bromophenylboronic acid to give 2.38 g (100%) of 4-(4-bromo-phenyl)-pyridine as a yellow solid, which had an NMR that matched literature (Boy, P.; Combellas, C.; Thiebault, A.; Amatore, C.; Jutand, A. Tetrahedron Lett. 1992, 33, 491-494) and was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06306892B1
Source datasetuspto-grants-2001_10
ORD IDord-301ed513dde645f49546c9cfbea7f0c0
Source noteuspto-grants-2001_10