HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromopyridine → 4-(4-Bromophenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromopyridine | HCID 14268 | — |
| Reactant | (4-Bromophenyl)boronic acid | HCID 79599 | — |
| Reactant | 3-(Biphenyl-4-yl)furan | HCID 18380293 | — |
| Product | 4-(4-Bromophenyl)pyridine | HCID 616283 | 100% |
Reaction Steps
According to the procedure described in Example 1(a) for the preparation of 3-biphenyl-4-yl-furan, 4-bromopyridine (700 mg, 3.00 mmol) underwent coupling to 4-bromophenylboronic acid to give 2.38 g (100%) of 4-(4-bromo-phenyl)-pyridine as a yellow solid, which had an NMR that matched literature (Boy, P.; Combellas, C.; Thiebault, A.; Amatore, C.; Jutand, A. Tetrahedron Lett. 1992, 33, 491-494) and was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306892B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-301ed513dde645f49546c9cfbea7f0c0 |
| Source note | uspto-grants-2001_10 |