N-methyl-3(R)-[3-[4-(pyndin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester → N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid

HRID 382174Notes

Reaction equation

HRID 382174 reaction equation
C([O:8][C:9](=[O:33])[CH2:10][C@@H:11]([N:16]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:17]1)[C:12]([NH:14][CH3:15])=[O:13])C1C=CC=CC=1>C(O)(=O)C>[CH3:15][NH:14][C:12](=[O:13])[C@H:11]([N:16]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[CH:29][N:30]=[CH:31][CH:32]=3)=[CH:23][CH:22]=2)=[CH:17]1)[CH2:10][C:9]([OH:33])=[O:8]

Participants

3

Reactant 1

HCID 53874083N-methyl-3(R)-[3-[4-(pyndin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester

Product 1

HCID 54315845N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acidYield 90%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

According to the procedure described in Example 7(a), N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester was hydrogenolyzed in acetic acid to yield in 90% yield N-methyl-3(R)-[3-[4-(pyridin4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid as a yellow amorphous solid.

Sources & evidence

ORD record
ord-f677a209fe7b450c9c1d59a7ec143cca
Source dataset
uspto-grants-2001_10
Patent number
US06306892B1

Reaction notes

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