Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 88229426, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | O-(tert-Butyldiphenylsilyl)hydroxylamine | HCID 11737343 | — |
| 반응물 | N-(2,2-dimethyl-1(S)-hydroxymethyl-propyl)-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid | HCID 15487948 | — |
| 반응물 | 3(R)-t-butoxycarbonylamino-N-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)succinamic acid benzyl ester | HCID 53706532 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | HCID 88229426 | HCID 88229426 | 43% |
반응 단계
According to the procedure described in Example 1(b) for the preparation of 3(R)-t-butyloxycarbonylamino-N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)succinamic acid benzyl ester, N-(2,2-dimethyl-1(S)-hydroxymethyl-propyl)-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid (prepared as described in Example 5(a)) and t-butyldiphenylsiloxyamine were coupled with TBTU. Flash column chromatography with 0-5% MeOH/CH2Cl2 gradient eluant furnished in 43% yield N1-t-butyldiphenylsiloxy-N4-[2,2-Dimethyl-1(S)-(hydroxymethyl)propyl]-2(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamide as an amorphous solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06306892B1 |
| 출처 데이터셋 | uspto-grants-2001_10 |
| ORD ID | ord-f1b87d184ed1493fb304717ef7e469d1 |
| 출처 메모 | uspto-grants-2001_10 |