HRID382195

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)C[C@H](NC(=O)[C@@H](CC(=O)OCc1ccccc1)c1ccn(-c2ccc(-c3ccc(C#N)cc3)cc2)c1)c1ncc[nH]1

HCID59932754

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@@H](CC(=O)O)c1ccn(-c2ccc(-c3ccc(C#N)cc3)cc2)c1)c1ncc[nH]1

HCID54295258

未命名化合物

收率 54%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21873804

未命名化合物

PROCEDURE

实验过程

According to the procedure described in Example 1(a), 3(S)-[1-(4′-cyanobiphenyl-4-yl)-1H-pyrrol-3-yl]-N-[1(S)-(1H-imidazol-2-yl)-3-methylbutyl]succinamic acid benzyl ester was hydrogenolyzed in EtOH/THF for 3h to give a 54% yield of 3(S)-[1-(4′-cyanobiphenyl-4-yl)-1H-pyrrol-3-yl]-N-[1(S)-(1H-imidazol-2-yl)-3-methylbutyl]succinamic acid: mp 206-210° C. (dec);

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aae600dc579c424c970e6150b904ac3b
来源数据集: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06306892B1
来源说明: uspto-grants-2001_10

反应 SMILES

C([O:8][C:9](=[O:44])[CH2:10][C@@H:11]([C:25]1[CH:29]=[CH:28][N:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]3[CH:41]=[CH:40][C:39]([C:42]#[N:43])=[CH:38][CH:37]=3)=[CH:32][CH:31]=2)[CH:26]=1)[C:12]([NH:14][C@H:15]([C:20]1[NH:21][CH:22]=[CH:23][N:24]=1)[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:13])C1C=CC=CC=1>CCO.C1COCC1>[C:42]([C:39]1[CH:40]=[CH:41][C:36]([C:33]2[CH:32]=[CH:31][C:30]([N:27]3[CH:28]=[CH:29][C:25]([C@@H:11]([C:12]([NH:14][C@H:15]([C:20]4[NH:24][CH:23]=[CH:22][N:21]=4)[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:13])[CH2:10][C:9]([OH:44])=[O:8])=[CH:26]3)=[CH:35][CH:34]=2)=[CH:37][CH:38]=1)#[N:43]