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HRID382197

反应详情

EQUATION

反应方程式

HRID 382197 的结构方程式

REACTANTS

反应物

1
结构：CC1(C)COC(=O)[C@H]1NC(=O)[C@@H](CC(=O)OCc1ccccc1)c1ccn(-c2ccc(-c3ccc(C#N)cc3)cc2)c1
HCID59932685

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)COC(=O)[C@H]1NC(=O)[C@@H](CC(=O)O)c1ccn(-c2ccc(-c3ccc(C#N)cc3)cc2)c1
HCID9804811

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.CCOC(C)=O
溶剂HCID21584252

未命名化合物

PROCEDURE

实验过程

According to the procedure described in Example 1(a), 3(S)-[1-(4′-cyanobiphenyl-4-yl)-1H-pyrrol-3-yl]-N-(4, 4-dimethyl-2-oxo-tetrahydrofuran-3 (S)-yl)succinamic acid benzyl ester was hydrogenolyzed in EtOH/EtOAc for 3h to give a 81% yield of 3(S)-[1-(4′-cyanobiphenyl-4-yl)-1H-pyrrol-3-yl]-N-(4, 4-dimethyl-2-oxo-tetrahydrofuran-3(S)-yl)succinamic acid: