HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → 2-(2-Biphenyl-4-yl-furan-5-yl)-2-oxoacetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 2-Biphenyl-4-yl-furan | HCID 11042255 | — |
| Reactant | 1-(4(S)-benzyl-2, 2-dimethyl-oxazolidin-3-yl)-2-(biphenyl-4-yl-1H-pyrrol-3-yl)ethane-1, 2-dione | HCID 18341258 | — |
| Product | 2-(2-Biphenyl-4-yl-furan-5-yl)-2-oxoacetic acid ethyl ester | HCID 18341512 | 74% |
Reaction Steps
According to the procedure described in Example 13 for the preparation of 1-(4(S)-benzyl-2,2-dimethyl-oxazolidin-3-yl)-2-(biphenyl-4-yl-1H-pyrrol-3-yl)ethane-1,2-dione, 2-biphenyl-4-yl-furan was deprotonated and alkylated with diethyl oxalate to give in 74% yield 2-(2-biphenyl-4-yl-furan-5-yl)-2-oxoacetic acid ethyl ester as a yellow solid, mp 91-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06306892B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-b1a250579bdc4bbabf4506fc78284347 |
| Source note | uspto-grants-2001_10 |