1,1'-Biphenyl-4-yl-boronic acid → 1-(4(S)-benzyl-2,2-dimethyl-oxazolidinyl)-2-(4-biphenyl4-yl-pyrazol-1-yl)-ethanone

Participants

Reaction Steps

According to the procedure described in Example 1(a) for the preparation of 3-biphenyl-4-yl-furan, 1-(4(S)-benzyl-2,2-dimethyl-oxazolidinyl)-2-(4-iodopyrazol-1-yl)-ethanone was coupled to 4-biphenylboronic acid to provide in 39% yield 1-(4(S)-benzyl-2,2-dimethyl-oxazolidinyl)-2-(4-biphenyl-4-yl-pyrazol-1-yl)-ethanone as a white solid, mp 150-1° C.

Provenance & Evidence