(S)-4-Benzyl-2-oxazolidinone → HCID 18341341, compound

HRID 382214Notes

Reaction equation

HRID 382214 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:21])[CH2:15][C:16]1SC=[CH:19][CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:22]1C=CC(CC(Cl)=O)=[CH:23]1.C([C@H]1COC(=O)N1)C1C=CC=CC=1>>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:21])[CH2:15][C:16]1[CH:20]=[CH:19][S:22][CH:23]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 736225(S)-4-Benzyl-2-oxazolidinoneHCID 27606223-Thiopheneacetyl chlorideHCID 18341340HCID 18341340, compound

Product 1

HCID 18341341HCID 18341341, compoundYield 68%

Procedure

According to the procedure described in Example 17(a) for the preparation of 4(S)-benzyl-3-(2-thien-2-yl-acetyl)-2-oxazolidinone, 3-thiopheneacetyl chloride and (S)-(−)-4-benzyl-2-oxazolidinone furnished in 68% yield 4(S)-benzyl-3-(2-thien-3-yl-acetyl)-2-oxazolidinone as a solid, mp 80-1° C.

Sources & evidence

ORD record
ord-cf4c09a8272543d6b4ff90cb287e2bbb
Source dataset
uspto-grants-2001_10
Patent number
US06306892B1

Reaction notes

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