HCID 53692494, compound → HCID 18341319, compound

HRID 382218Notes

Reaction equation

HRID 382218 reaction equation
C([O:8][C:9](=[O:39])[CH2:10][CH:11]([N:22]1[CH:26]=[CH:25][N:24]([C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:29][CH:28]=2)[CH2:23]1)[C:12]([NH:14][C@H:15]([CH2:20][OH:21])[C:16]([CH3:19])([CH3:18])[CH3:17])=[O:13])C1C=CC=CC=1>CCO>[C:30]1([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:29]=[CH:28][C:27]([N:24]2[CH:25]=[CH:26][N:22]([CH:11]([C:12]([NH:14][C@H:15]([CH2:20][OH:21])[C:16]([CH3:17])([CH3:19])[CH3:18])=[O:13])[CH2:10][C:9]([OH:39])=[O:8])[CH2:23]2)=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 53692494HCID 53692494, compound

Product 1

HCID 18341319HCID 18341319, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the procedure described in Example 1(a), a suspension of 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(2,2-dimethyl-1(S)-hydroxymethylpropyl)succinamic acid benzyl ester in EtOH was hydrogenated to provide 3(RS)-(3-biphenyl-4-yl-1H-imidazol-1-yl)-N-(2,2-dimethyl-1(S)-hydroxymethylpropyl)succinamic acid as a solid, mp 145-50° C.

Sources & evidence

ORD record
ord-1719906cbffc47d1bf18288ad0504697
Source dataset
uspto-grants-2001_10
Patent number
US06306892B1

Reaction notes

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