HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → 5-Trimethylsilanylethynyl-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 5-Iodo-1H-indazole | HCID 21894739 | — |
| Product | 5-Trimethylsilanylethynyl-1H-indazole | HCID 57950741 | 46% |
Reaction Steps
In an adaption of GP 8a, 5-Iodo-1H-indazole (0.98 g, 4.02 mmol) was reacted with trimethylsilyl acetylene (0.60 mL, 4.22 mmol) at 90° C. for 5 h to give 395 mg (46%) of pure 5-(trimethylsilyl)ethynyl-1H-indazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524724B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-48f24bc4b67e42c4b5bb022545ea44f0 |
| Source note | uspto-grants-2013_09 |