反应详情

To a solution of 3-ethynyl aniline (1.05 mL, 10.0 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (857 μL, 1.10 eq.) at a temperature of 0° C. The resulting mixture was stirred overnight at room temperature and was then evaporated. The residue was treated with 2 N aq. HCl (25 mL) and subsequently extracted with ethyl acetate (2×30 mL). The combined organic layers were dried over MgSO4 and evaporated to give the desired methanesulfonamide in quantitative yield. It was used without further purification.

1. customwas then evaporated
2. additionThe residue was treated with 2 N aq. HCl (25 mL)
3. extractionsubsequently extracted with ethyl acetate (2×30 mL)
4. dry with materialThe combined organic layers were dried over MgSO4
5. customevaporated