HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Glycine methyl ester N-(butoxycarbonyl)pipecolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Reactant | 1-[(Tert-butoxy)carbonyl]piperidine-2-carboxylic acid | HCID 581831 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | EtOAc isooctane | HCID 18516502 | — |
| Product | Glycine methyl ester N-(butoxycarbonyl)pipecolinamide | HCID 70024518 | — |
Reaction Steps
1-(tertButoxycarbonyl)-2-piperidinecarboxylic acid (11.46 g, 1.2 eq), glycine methyl ester hydrochloride (9.42 g), 1-(dimethylaminopropyl)-3-(ethyl)carbodiimide hydrochloride (8.00 g, 1.0 eq) and Et3N (16.3 mL) were reacted as described in Example 1 to give 5.6 g of the title compound as a colorless crystallinesolid: mp 118.5-119.5° C. (EtOAc/isooctane 1:3);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310064B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-6ab6b134d9d349a0a67fd8918d56b30c |
| Source note | uspto-grants-2001_10 |