反应详情

A mixture of tert-butyl-4-(N′-hydroxycarbamimidoyl)-3-methyl-1H-pyrazole-1-carboxylate (7.91 mmol, 1.90 g), Pd/C (190 mg) and anhydride acetic (7.91 mmol, 0.81 g) in MeOH (50 mL) was stirred at room temperature for 6 hours under hydrogen atmosphere. After filtration and evaporation of the solvent, the crude product was triturated with Et2O and dried to yield 3-methyl-1H-pyrazole-4-carboxamidine acetate (1.21 g, 6.57 mmol, 83%) as a white solid.

1. filtrationAfter filtration and evaporation of the solvent
2. customthe crude product was triturated with Et2O
3. customdried