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Sodium hydride → 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | 1-(2-Bromoethoxy)-4-nitrobenzene | HCID 235987 | — |
| 反応物 | 2-Ethyl-6-methylpyrimidin-4(1h)-one | HCID 135417368 | — |
| 生成物 | 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene | HCID 21960135 | 30.9% |
反応手順
The title compound (5.2 g, 25%) was prepared from 2-ethyl-4-methyl-1,6-dihydro-6-pyrimidone (7.65 g, 55.43 mmol), 4-[2-bromoethoxy]nitrobenzene (15.0 g, 60.97 mmol), LiBr (11.09 g, 127.49 mmol) and 60% NaH (2.76 g, 72.06 mmol) as base by a similar procedure to that described in preparation 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310069B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-b3a6d3a25b294347b15ecbc3d6357ba6 |
| 出典メモ | uspto-grants-2001_10 |