Sodium Hydroxide → HCID 18360725, compound

Participants

Reaction Steps

A solution of 6.2 g of the compound obtained in Step A in 50 ml of anhydrous THF is added dropwise to a suspension of 1.42 g of lithium aluminum hydride in 50 ml of anhydrous THF cooled in an ice-bath. After stirring for 30 minutes at room temperature, a solution of 5% sodium hydroxide is added dropwise until the evolution of gas ceases. The precipitate that forms is filtered off, the organic phase is evaporated and the residue is taken up in 70 ml of ethyl acetate. The organic phase is washed with water until neutrality, dried over magnesium sulphate and evaporated in vacuo to yield the title product in the form of an oil.

Provenance & Evidence