Ammonia → HCID 10730177, compound

Participants

Reaction Steps

Following standard procedure C, methyl 2-(4′-cyanophenyl)-1-H-benzimidazole-4-carboxylate (169.5 mg, 0.612 mmol) was treated with ammonia under pressure. The crude product was recrystallised from boiling methanol to yield the title compound pure as white crystals. (116.5 mg, 73%) mp >310° C.; Found C 67.81 H 3.89 N 20.87, C15H10N4O.0.2 MeOH Requires C 67.95 H 4.05 N 20.85; vmax(cm−1) 3332.27, 3274.86, 3177.98, 2230.85, 1658.54, 1608.10; δH 7.45-7.49 (1H, t); 7.87-7.91 (1H, d), 7.91 (1H, br s), 7.98-8.02 (1H, d); 8.13-8.17 (2H, d, J=8.3), 8.50-8.54 (2H, d, J=8.3), 9.2-9.4 (1H, br s), 13.6-13.8 (1H, br 8); m/z (EI) 262 (M+), 245, 217, 102.

Provenance & Evidence