Ammonia → HCID 10852098, compound

Participants

Reaction Steps

Following standard procedure C, the acetate salt of methyl 2-(3′-trifluoromethylphenyl)-1-H-benzimidazole-4-carboxylate (134.8 mg, 0.358 mmol) was treated with excess liquid ammonia in a sealed vessel. The product was purified by recrystallisation from methanol, to yield off-white needles. (78 mg, 72%). mp 268-270° C.; Found C 57.68 H 3.82 N 12.96 C15H10F3N3O.0.6CH3OH Requires C 57.74 H 3.82 N 12.95; vmax(cm−1) 3488.83, 3348.86, 3176.45, 1667.66, 1600.93, 1329.63; δH 7.44-7.52 (1H, t), 7.88-8.04 (5H, m), 8.66-8.70 (1H, d), 8.70 (1H, s, 2′ H), 9.3 (1H, br s, NH), 13.6 (1H, br s, NH); m/z (EI) 305 (M+), 288, 260, 145.

Provenance & Evidence