Benzoyl chloride → 7-Benzyl-2-(3,5-di-t-butyl-4-methoxymethoxyphenyl)hypoxanthine

Participants

Reaction Steps

An amidation reaction was performed following the same conditions as in Example 1 using 2.2 g (10 mmol) of 4-amino-1-benzyl-5-imidazole carboxamide obtained in Reference Example 2 and using, instead of benzoyl chloride, 3,5-di-t-butyl-4-methoxymethoxybenzoyl chloride which was separately prepared by a conventional method. After a post-treatment, a crude amide product was obtained. The crude amide was subjected to a cyclization reaction for 12 hours according to the same conditions as in Example 1. 2.17 g of 7-benzyl-2-(3,5-di-t-butyl-4-methoxymethoxyphenyl)hypoxanthine was obtained after a post-treatment. Yield 45% (2 steps).

Provenance & Evidence