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Benzoyl chloride → 1-Benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| 反応物 | 3,5-Dimethyl-4-methoxymethoxybenzoyl chloride | HCID 18360534 | — |
| 生成物 | 1-Benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide | HCID 18360488 | — |
反応手順
An amidation reaction and post-treatment were carried out according to the conditions of Example 1, using 1.06 g (4.9 mmol) 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and, instead of benzoyl chloride, 3,5-dimethyl-4-methoxymethoxybenzoyl chloride which was separately prepared by a conventional method, to obtain 1.40 g of 1-benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-96dc6dc797a3496d86589f71b1f7ccb1 |
| 出典メモ | uspto-grants-2001_10 |