Benzoyl chloride → 1-Benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide

Participants

Role	Name	HCID	Charge
Reactant	Benzoyl chloride	HCID 7412	—
Reactant	1-benzyl-4-amino-1H-imidazole-5-carboxamide	HCID 14000620	—
Reactant	3,5-Dimethyl-4-methoxymethoxybenzoyl chloride	HCID 18360534	—
Product	1-Benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide	HCID 18360488	—

Reaction Steps

An amidation reaction and post-treatment were carried out according to the conditions of Example 1, using 1.06 g (4.9 mmol) 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and, instead of benzoyl chloride, 3,5-dimethyl-4-methoxymethoxybenzoyl chloride which was separately prepared by a conventional method, to obtain 1.40 g of 1-benzyl-4-(3,5-dimethyl-4-methoxymethoxybenzoyl-amino)-5-imidazolecarboxamide.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06310070B1
Source dataset	uspto-grants-2001_10
ORD ID	ord-b76a6626e6194dd88d3e741e6ba03d71
Source note	uspto-grants-2001_10