HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → 1-Benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 3,5-Dimethylbenzoyl Chloride | HCID 81088 | — |
| Reactant | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| Product | 1-Benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamide | HCID 18360362 | 91% |
Reaction Steps
An amidation reaction and post-treatment were carried out according to the conditions of Example 1, using 6.54 g (30.2 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and, instead of benzoyl chloride, 3,5-dimethylbenzoyl chloride which was separately prepared by a conventional method, to obtain 9.62 g of 1-benzyl-4-(3,5-dimethylbenzoylamino)-5-imidazolecarboxamide (yield 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310070B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-a6bdc99263694f718cdc586144934036 |
| Source note | uspto-grants-2001_10 |