2-Fluorobenzoyl chloride → HCID 18360149, compound

HRID 382371Notes

Reaction equation

HRID 382371 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>>[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:21]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Product 1

HCID 18360149HCID 18360149, compoundYield 97%

Procedure

An amidation reaction and post-treatment were carried out according to the conditions of Example 1, using 2.2 g (10 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain a crude amide product. The crude amide product was purified by suspension in hot methanol to obtain 1.69 g of 4-(2-fluorobenzoylamino)-1-benzyl-5-imidazolecarboxamide (yield 97%).

Workup

  1. customAn amidation reaction
  2. customto obtain a crude amide product
  3. customThe crude amide product was purified by suspension in hot methanol

Sources & evidence

ORD record
ord-1df552d4dda642ce92547c1dccd51591
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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