Acetyl chloride → HCID 18360517, compound

Participants

Reaction Steps

An amidation reaction and a post-treatment were carried out according to the conditions of Example 18, using 2.2 g (10 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in Reference Example 2 and cyclohexanecarbonyl chloride separately prepared according to a conventional method, instead of acetyl chloride, to obtain a crude crystals. The crude crystals were purified by suspension in hot methanol to obtain 1.62 g of 4-cyclohexylcarbonylamino-1-benzyl-5-imidazolecarboxamide (yield 49%).

Provenance & Evidence