Hydrochloric Acid → HCID 18360278, compound

Participants

Reaction Steps

The benzylidation reaction in N,N-dimethylformamide-distilled water, benzylidene de-protection reaction with hydrochloric acid, and neutralization reaction of hydrochloride with sodium hydroxide were carried out in the same manner as in Example 71, using the benzyl chloride, 1.95 g (9.1 mmol) of 4-benzylideneamino-5-imidazolecarboxamide, and 5.03 g (36.4 mmol) of potassium carbonate, to obtain 2.44 g of 4-amino-1-(4-benzyloxy-3,5-di-t-butylbenzyl)-5-imidazolecarboxamide (yield 77%).

Provenance & Evidence