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3-Pyridineacetic acid, hydrochloride (1:1) → 4-(3-(N-t-butyloxycarbonyl-N-methylamino)propanoylamino)-1-benzyl-5-imidazole carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| 反応物 | 3-(Methylamino)propanoic acid, N-BOC protected | HCID 2760952 | — |
| 反応物 | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| 生成物 | 4-(3-(N-t-butyloxycarbonyl-N-methylamino)propanoylamino)-1-benzyl-5-imidazole carboxamide | HCID 18360179 | 72% |
反応手順
An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 1.92 g (8.96 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide which was prepared in the same manner as in Reference Example 2 and 3-(N-t-butyloxycarbonyl-N-methylamino)propionic acid, instead of 3-pyridylacetic acid hydrochloride, to obtain 2.56 g of 4-(3-(N-t-butyloxycarbonyl-N-methylamino)propanoylamino)-1-benzyl-5-imidazole carboxamide (yield 72%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06310070B1 |
| 出典データセット | uspto-grants-2001_10 |
| ORD ID | ord-0e35a30f0acc412187e8f039f1731b5f |
| 出典メモ | uspto-grants-2001_10 |