HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridineacetic acid, hydrochloride (1:1) → 4-(4-(N-t-butyloxycarbonyl-N-methylamino)butanoylamino)-1-benzyl-5-imidazole carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| Reactant | 4-{[(Tert-butoxy)carbonyl](methyl)amino}butanoic acid | HCID 10656390 | — |
| Reactant | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| Product | 4-(4-(N-t-butyloxycarbonyl-N-methylamino)butanoylamino)-1-benzyl-5-imidazole carboxamide | HCID 18360599 | 67% |
Reaction Steps
An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 1.44 g (6.72 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide which was prepared in the same manner as in Reference Example 2 and 4-(N-t-butyloxycarbonyl-N-methylamino)butanoic acid, instead of 3-pyridylacetic acid hydrochloride, to obtain 1.86 g of 4-(4-(N-t-butyloxycarbonyl-N-methylamino)butanoylamino)-1-benzyl-5-imidazole carboxamide (yield 67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310070B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-7d755b3153b64499b600c144d29be094 |
| Source note | uspto-grants-2001_10 |