2-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide

Participants

Reaction Steps

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.91 g (7.01 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.47 g of 1-(4-t-butylbenzyl)-4-(2-fluorobenzoylamino)-5-imidazolecarboxamide (yield 89%).

Provenance & Evidence