2-Fluorobenzoyl chloride → HCID 18360342, compound

HRID 382402Notes

Reaction equation

HRID 382402 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:22]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 18360432HCID 18360432, compound

Product 1

HCID 18360342HCID 18360342, compound

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 22 using 2.00 g (8.69 mmol) of 4-amino-1-(2-phenylethyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 56 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain crude 4-(2-fluorobenzoylamino)-1-(2-phenylethyl)-5-imidazolecarboxamide.

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-12ba5f00a2b744e1a25ba2705fe477c9
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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