Nicotinic Acid → HCID 18360537, compound

HRID 382404Notes

Reaction equation

HRID 382404 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:19](O)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[CH2:10][N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:19]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)=[O:26])[N:3]=[CH:4]1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 18360238HCID 18360238, compound

Product 1

HCID 18360537HCID 18360537, compoundYield 62%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 19, using 2.96 g (12.0 mmol) of 4-amino-1-(3-methoxybenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 81 and nicotinic acid instead of cyclopentylacetic acid to obtain 2.61 g of 1-(3-methoxybenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 62%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-a90f71aa156547b0b347524a7572b845
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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