Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → HCID 18360117, compound

HRID 382409Notes

Reaction equation

HRID 382409 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18]([O:22][C:23]([N:25]([CH2:27][C:28](O)=[O:29])[CH3:26])=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([N:25]([CH2:27][C:28]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:29])[CH3:26])=[O:24])([CH3:21])([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-HCID 18360432HCID 18360432, compound

Product 1

HCID 18360117HCID 18360117, compoundYield 94%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 1.84 g (7.99 mmol) of 4-amino-1-(2-phenylethyl)-5-imidazolecarboxamide prepared in the same manner as in Example 56 and 2-(N-t-butyloxycarbonyl-N-methylamino)acetic acid instead of 3-pyridylacetic acid hydrochloride to obtain 3.03 g of 4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-1-(2-phenylethyl)-5-imidazolecarboxamide (yield 94%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-d9276371e61f4336879e0c45cc842a1e
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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