3-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide

Participants

Reaction Steps

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.54 g (5.65 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 3-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.57 g of 1-(4-t-butylbenzyl)-4-(3-fluorobenzoylamino)-5-imidazolecarboxamide (yield 70%).

Provenance & Evidence