4-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide

Participants

Reaction Steps

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 2.63 g (9.66 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 4-fluorobenzoyl Chloride instead of benzoyl chloride to obtain 2.13 g of 1-(4-t-butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide (yield 56%).

Provenance & Evidence