Nicotinic Acid → HCID 18360422, compound

HRID 382421Notes

Reaction equation

HRID 382421 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:19](O)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>>[C:13]1([CH2:12][CH2:11][CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:19]([C:20]3[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=3)=[O:26])[N:3]=[CH:4]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 18360337HCID 18360337, compound

Product 1

HCID 18360422HCID 18360422, compound

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.00 g (8.19 mmol) of 4-amino-1-(3-phenylpropyl)-5-imidazolecarboxamide prepared in the same manner as in Example 114 and nicotinic acid instead of 3-pyridylacetic acid hydrochloride to obtain crude 1-(3-phenylpropyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide.

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-bf23285f48c04790a519db7b5548b355
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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