Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → HCID 18360614, compound

HRID 382422Notes

Reaction equation

HRID 382422 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:19]([O:23][C:24]([N:26]([CH2:28][C:29](O)=[O:30])[CH3:27])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([N:26]([CH2:28][C:29]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:30])[CH3:27])=[O:25])([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-HCID 18360337HCID 18360337, compound

Product 1

HCID 18360614HCID 18360614, compoundYield 94%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.00 g (8.19 mmol) of 4-amino-1-(3-phenylpropyl)-5-imidazolecarboxamide prepared in the same manner as in Example 114 and 2-(N-t-butyloxycarbonyl-N-methylamino)acetic acid instead of 3-pyridylacetic acid hydrochloride to obtain 3.20 g of 4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-1-(3-phenylpropyl)-5-imidazolecarboxamide (yield 94%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-d2eee6ad885a4f049206fa2a085cda79
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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