HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridineacetic acid, hydrochloride (1:1) → HCID 54341202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| Reactant | 4-[(tert-Butoxycarbonyl)(methyl)amino]benzoic acid | HCID 11172762 | — |
| Reactant | 1-benzyl-4-amino-1H-imidazole-5-carboxamide | HCID 14000620 | — |
| Product | HCID 54341202 | HCID 54341202 | 69% |
Reaction Steps
An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.16 g (9.99 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in the same manner as in Reference Example 2 and, instead of 3-pyridylacetic acid hydrochloride, 4-(N-t-butyloxycarbonyl-N-methylamino)benzoic acid which was prepared separately by a conventional method, to obtain 3.10 g of 1-benzyl-4-(4-(N-t-butyloxycarbonyl-N-methylamino) benzoylamino)-5-imidazolecarboxamide (yield 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06310070B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-fddabfd478164ef6818ec44525a99b86 |
| Source note | uspto-grants-2001_10 |