Benzoyl chloride → 1-(4-t-Butylbenzyl)-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamide

Participants

Reaction Steps

An amidation reaction and post-treatment were carried out following the conditions of Example 1, using 1.63 g (5.28 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide hydrochloride prepared in the same manner as in Example 57 and, instead of benzoyl chloride, isonicotinic chloride which was prepared separately by a conventional method, to obtain 1.78 g of 1-(4-t-butylbenzyl)-4-(4-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 89%).

Provenance & Evidence