反应详情

2.17 g (5.81 mmol) of the amide thus prepared was suspended in 30 ml of toluene and 5.00 g (24.3 mmol) of trimethyl tin azide was added to the suspension, followed by heating for 23 hours while refluxing. Crystals produced was separated by filtration and dissolved in methanol containing 1N hydrochloric acid. The solution was neutralized with 4 N sodium hydroxide aqueous solution. After evaporating methanol, crystals collected by filtration was purified by suspending them in hot methanol, thereby obtaining 1.93 g of 2-ethyl-7-(4-2-tetrazolylphenyl)benzyl)hypoxanthine (yield 83%).

1. temperatureby heating for 23 hours
2. temperaturewhile refluxing
3. customCrystals produced
4. customwas separated by filtration
5. dissolutiondissolved in methanol containing 1N hydrochloric acid
6. customAfter evaporating methanol, crystals
7. filtrationcollected by filtration
8. customwas purified