反应详情

温度

80 °C

According to Scheme 3 Step 1 Method B: 2-Bromopyrimidine (1.26 mmol, 211 mg) was added to a suspension of 2-methoxy-4-nitrophenol (1.15 mmol, 200 mg), Cs2CO3 (1.41 mmol, 460 mg) in DMF (3 mL). The reaction mixture was stirred at 80° C. for 3 days. The reaction mixture was quenched with water. The aqueous phase was extracted with AcOEt. The organic phase was washed with brine, was dried over MgSO4, was filtered and was concentrated under reduced pressure. The crude product was washed with a solution of NaOH 3M and dried to obtain 2-(2-methoxy-4-nitrophenoxy)pyrimidine (0.89 mmol, 220 mg, 78%) as a solid. The product was used without further purification.

1. customThe reaction mixture was quenched with water
2. extractionThe aqueous phase was extracted with AcOEt
3. washThe organic phase was washed with brine
4. dry with materialwas dried over MgSO4
5. filtrationwas filtered
6. concentrationwas concentrated under reduced pressure
7. washThe crude product was washed with a solution of NaOH 3M
8. customdried