反应详情

温度

16 °C

A 12 liter flask fitted with a mechanical stirrer, a constant addition funnel, a thermometer, and a reflux condenser was charged with of 5-octyl-2-(4-hydroxyphenyl)pyrimidine (300 g, 1.05 mol), perfluorobutanesulfonyl fluoride (378 g, 1.25 mol), and tert-butylmethylether (3 L) under positive nitrogen pressure and was cooled with an ice bath to 16° C. 1,8-Diazabicyclo[5.4.0]undec-7-ene (180 g, 1.18 mol) was added to the resulting mixture over 25 minutes, while maintaining the temperature of the mixture below 20° C. After the addition was complete, the mixture was stirred at room temperature for 2 hours, and then 3 liters of water was added. The resulting aqueous phase was separated from the resulting organic phase, and the organic phase was washed with a mixture of 2.25 liters of water and 0.75 liters of concentrated HCl. The solvent was removed from the organic phase under reduced pressure to yield 697 g of crude product, which was recrystallized from ethanol to yield 4-(5-octyl pyrimidine-2-yl)phenyl nonafluorobutane sulfonate (499 g, 84% yield).

1. customA 12 liter flask fitted with a mechanical stirrer, a constant addition funnel
2. temperaturewhile maintaining the temperature of the mixture below 20° C
3. additionAfter the addition
4. customThe resulting aqueous phase was separated from the resulting organic phase
5. washthe organic phase was washed with a mixture of 2.25 liters of water and 0.75 liters of concentrated HCl
6. customThe solvent was removed from the organic phase under reduced pressure
7. customto yield 697 g of crude product, which
8. customwas recrystallized from ethanol