Ethyl Acetate → HCID 9947145, compound

Participants

Reaction Steps

To a solution of potassium carbonate (32.3 g) in distilled water(120 ml) was added ethyl acetate (120 ml), and (R)-3-[5-(2-aminopropyl)-7-cyano-2,3-dihydro-1H-indol-1-yl]propyl benzoate L-tartrate (12.0 g) was added portionwise to the mixture with stirring. After reaction for 1 hour, the reaction mixture was extracted with ethyl acetate, and the ethyl acetate layer was washed with 10% aqueous potassium carbonate solution and brine subsequently, and dried over anhydrous sodium sulfate. The solvent was removed in vacuo to give (R)-3-[5-(2-aminopropyl)-7-cyano-2,3-dihydro-1H-indol-1-yl]propyl benzoate (8.98 g) as a brown oil.

Provenance & Evidence