Ammonium formate → HCID 15887031, compound

Participants

Reaction Steps

tert-Butyl (R)-N-[2-[7-carbamoyl-1-(3-hydroxy-propyl)-2,3-dihydro-1H-indol-5-yl]-1-methylethyl]-N-[2-(2-ethoxyphenoxy)ethyl]carbamate (4.93 g) was dissolved in methanol (150 ml), and 10% palladium on carbon (490 mg) and ammonium formate (2.96 g) were added to the solution. After the mixture was heated under reflux for 36 hours and cooled, the insoluble material was filtered off. The solvent was removed in vacuo, and the residue was dissolved in methanol (150 ml). 10% Palladium on carbon (490 mg) and ammonium formate (2.96 g) were added to the solution. After the mixture was heated under reflux for 24 hours and cooled, the insoluble material was filtered off. The filtrate was concentrated in vacuo, and the residue was dissolved in ethyl acetate. The solution was washed with water and brine, and dried over anhydrous sodium sulfate. The solvent was removed in vacuo to give white amorphous tert-butyl (R)-N-[2-[7-carbamoyl-1-(3-hydroxypropyl)-1H-indol-5-yl]-1-methylethyl]-N-[2-(2-ethoxyphenoxy)ethyl]-carbamate (4.55 g).

Provenance & Evidence